Sevilla and Atletico Madrid could only be separated by two points last season as the former finished fifth and the latter finished third.
Since then the two sides have had a massive influx of players as they look to bridge the gap to the top two (Barcelona and Real Madrid).
Sevilla have home advantage but Madrid have not lost to them in since 2010. Atletico also won their opening fixture against Las Palmas, whilst drew 0-0 against Malaga and suffered the igmoniny of Steven N'zonzi being sent-off on his debut. The former Blackburn and Stoke man will miss this game as a result.
Team sheets below: