The last time these two sides met, Southampton were in the middle of a losing streak and Manchester United were in the middle of a winning streak; needless to say, United won that match 2-1.
However, the two sides are only separated by one point and one place in the league table, suggesting fortunes have changed. Indeed, United's form has slowed down somewhat as they have drawn twice in a row and have drawn three times in the last four games. Meanwhile, Southampton have won three of the last four games.
If there is a slight indication regarding a possible winner in this tough-to-call fixture, it is found in the head-to-head. Since Southampton gained promotion to the Premier League, they have yet to beat United, losing three times and drawing twice. However, every single one of those matches were competitive with only one goal separating the sides when Southampton lost. Furthermore, Southampton have always scored against Manchester United during this sequence of games.
I do not envy who has to call this game, though perhaps a look at the starting line-ups might help them?