Liverpool: Adam Lallana, Daniel Agger, Lazar Markovic & Jon Flanagan
Southampton: Jay Rodriguez
Liverpool and Southampton enjoyed great campaigns last season but have had to endure a difficult transfer window as their best players have left them. However, whereas Liverpool only lost one player of note, Luis Suarez; Southampton have lost several of their players.
Furthermore, Liverpool have been able to add to their overall depth of their squad, buying several players of Premier League experience. Finally, it is expected Liverpool will not initially rely too much on their new signings.
On the other hand, Southampton have only been able to replace those who have left, furthermore many of them do not have Premier League experience and they will be expected to produce the good straightaway.
With that in mind, Liverpool should be able to put Southampton to bed in their first game of the season.
Dejan Lovren was Southampton's paciest and best central defender, now a Liverpool player, Southampton have yet to replace him with a defender of his ilk.
Yoshida and Fonte will stand in for him and as long as Daniel Sturridge receives the service, he will feel confident in exploiting their weaknesses.
For that to happen, one of Liverpool's creative trio: Raheem Sterling, Philippe Coutinho and Steven Gerrard will need to step up. With Coutinho set to play on the right wing against left back Ryan Bertrand, Coutinho will be most likely to make an impact.
Bertrand has never been the best of defenders and with Coutinho's brand of dribbling, movement and creativity, he should have too much for the young English full back.
However, if attack is Liverpool's strength, Liverpool's weakness last season was their defending. With Glen Johnson in poor form and Javi Manquillo largely untested at this level, Southampton's new look attack could get some joy.
Last season Adam Lallana (now at Liverpool) enjoyed two very good games against Liverpool, though looking at Southampton's midfield, with wantaway midfielder Morgan Schneiderlin being the most creative, it is highly unlikely Southampton's attack will get any service, especially as Liverpool's midfield of Lucas, Gerrard and Henderson have enough power not to get overawed by Schneiderlin and Wanyama.
Liverpool 2-0 Southampton
*Daniel Sturridge to score
*Philippe Coutinho to assist a goal
*Wanyama and Lucas Leiva to receive a yellow card